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Article

Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity.

Thrombosis research - 1 Apr 2009

Monti Monia, Borensztajn Keren S, Pinotti Mirko, Canella Alessandro, Branchini Alessio, Marchetti Giovanna, Reitsma Pieter H, Bernardi Francesco, Spek C Arnold

Abstract excerpt

INTRODUCTION: Factor X (FX) is a serine-protease playing a crucial role in the blood coagulation pathway and triggering intracellular signalling in a variety of cells via protease-activated receptors (PARs). By exploiting naturally occurring variants (V342A and G381D, catalytic domain; E19A, gamma-carboxyglutamic acid (GLA)-rich domain), we investigated the relationship between the pro-coagulant activity and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19108874
DOI: 10.1016/j.thromres.2008.10.012

Genes

GLA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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