Article
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.
Journal of molecular biology - 5 Feb 1999
Zhang E, St Charles R, Tulinsky A
Abstract excerpt
The event that initiates the extrinsic pathway of blood coagulation is the association of coagulation factor VIIa (VIIa) with its cell-bound receptor, tissue factor (TF), exposed to blood circulation following tissue injury and/or vascular damage. The natural inhibitor of the TF.VIIa complex is t...
Topics
- Amino Acid Chloromethyl Ketones
- Amino Acid Sequence
- Aprotinin
- Catalytic Domain
- Crystallography, X-Ray
- Epidermal Growth Factor
- Factor IXa
- Factor VIIa
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Sequence Homology, Amino Acid
- Serine Proteinase Inhibitors
- Thromboplastin