Article
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Neale Benjamin M, Fagerness Jesen, Reynolds Robyn, Sobrin Lucia, Parker Margaret, Raychaudhuri Soumya, Tan Perciliz L, Oh Edwin C, Merriam Joanna E, Souied Eric, Bernstein Paul S, Li Binxing, Frederick Jeanne M, Zhang Kang, Brantley Milam A, Lee Aaron Y, Zack Donald J, Campochiaro Betsy, Campochiaro Peter, Ripke Stephan, Smith R Theodore, Barile Gaetano R, Katsanis Nicholas, Allikmets Rando, Daly Mark J, Seddon Johanna M
Abstract excerpt
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results of a genome-wide association study of 979 advanced AMD cases and 1,709 controls using the Affymetrix 6.0 platform with replication in seven additional cohorts (totaling 5,789 unrelated cases and 4,234 unrelated controls). We also present a comprehensive analysis of copy-number variations and...
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