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Article

High-Density Lipoproteins Associated with Age-Related Macular Degeneration in the All of Us Research Program.

Ophthalmology - 1 Jun 2025

Chen Jimmy S, Esko Jeffrey D, Walker Evan, Gordts Philip L S M, Baxter Sally L, Toomey Christopher B

Abstract excerpt

PURPOSE: Extracellular lipoprotein aggregation is a critical event in age-related macular degeneration (AMD) pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for AMD in the All of Us research program. DESIGN: Cross-sectional retrospective data analysis. PARTICIPANTS: A total of 5028 healthy participants and 2328...

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Aged, 80 and over
Cross-Sectional Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins, HDL
Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39756691
DOI: 10.1016/j.ophtha.2024.12.039
PMCID: PMC12097936

Genes

LPA
TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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