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The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population.

Acta ophthalmologica - 1 May 2020

Fernández-Vega Beatriz, García Montserrat, Olivares Lorena, Álvarez Lydia, González-Fernández Adrián, Artime Enol, Fernández-Vega Cueto Andrés, Cobo Teresa, Coca-Prados Miguel, Vega José A, González-Iglesias Héctor

Abstract excerpt

PURPOSE: To elucidate the potential role of eleven single nucleotide polymorphisms (SNPs) in the most relevant lipid metabolism genes in Northern Spanish patients with age-related macular degeneration (AMD). METHODS: A case-control study of 228 unrelated native Northern Spanish patients diagnosed with AMD (73 dry and 155 wet) and 95 healthy controls was performed. DNA was isolated from peripheral blood and...

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PMID: 31654486
DOI: 10.1111/aos.14280

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