Article
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme - 1 Apr 2010
Naples Scott P, Borengasser Sarah J, Rector R Scott, Uptergrove Grace M, Morris E Matthew, Mikus Catherine R, Koch Lauren G, Britton Steve L, Ibdah Jamal A, Thyfault John P
Abstract excerpt
Rats selected artificially to be low-capacity runners (LCR) possess a metabolic syndrome phenotype that is worsened by a high-fat diet (HFD), whereas rats selected to be high-capacity runners (HCR) are protected against HFD-induced obesity and insulin resistance. This study examined whether protection against, or susceptibility to, HFD-induced insulin resistance in the HCR-LCR strains is associated with...
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