Article
Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury.
The Journal of physiology - 15 Apr 2009
Thyfault John P, Rector R Scott, Uptergrove Grace M, Borengasser Sarah J, Morris E Matthew, Wei Yongzhong, Laye Matt J, Burant Charles F, Qi Nathan R, Ridenhour Suzanne E, Koch Lauren G, Britton Steve L, Ibdah Jamal A
Abstract excerpt
Fatty liver has been linked to low aerobic fitness, but the mechanisms are unknown. We previously reported a novel model in which rats were artificially selected to be high capacity runners (HCR) and low capacity runners (LCR) that in a sedentary condition have robustly different intrinsic aerobic capacities. We utilized sedentary HCR/LCR rats (generation 17; max running distance equalled 1514 +/- 91 vs. 200 +/-...
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