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Article

Aerobic capacity-dependent differences in cardiac gene expression

3 Jan 2008

Abstract excerpt

Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between inborn aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high and low running capacity (HCR and LCR, respectively) over 16 generations. The artificial selection of LCR caused accumulation of risk factors of cardiovascular disease...

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PMID: 18171719
DOI: 10.1152/physiolgenomics.00269.2007

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