Article
Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2010
Kivelä Riikka, Silvennoinen Mika, Lehti Maarit, Rinnankoski-Tuikka Rita, Purhonen Tatja, Ketola Tarmo, Pullinen Katri, Vuento Meri, Mutanen Niina, Sartor Maureen A, Reunanen Hilkka, Koch Lauren G, Britton Steven L, Kainulainen Heikki
Abstract excerpt
A strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle gene-phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12...
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