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Article

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.

Nature neuroscience - 1 May 2010

Magalhaes Ana C, Holmes Kevin D, Dale Lianne B, Comps-Agrar Laetitia, Lee Dennis, Yadav Prem N, Drysdale Linsay, Poulter Michael O, Roth Bryan L, Pin Jean-Philippe, Anisman Hymie, Ferguson Stephen S G

Abstract excerpt

Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R). However, the potential behavioral and cellular interaction between these two receptors is unclear. We found that pre-administration of corticotrophin-releasing factor (CRF) into the prefrontal cortex of mice enhanced...

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Identifiers

PMID: 20383137
DOI: 10.1038/nn.2529
PMCID: PMC2862362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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