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Article

Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems.

The European journal of neuroscience - 1 Nov 2008

Sandi Carmen, Cordero M Isabel, Ugolini Annarosa, Varea Emilio, Caberlotto Laura, Large Charles H

Abstract excerpt

The basolateral nucleus of the amygdala (BLA) plays a key role in emotional arousal and anxiety, and expresses high levels of corticotropin-releasing factor receptor (CRFR)1. In rat brain slices, we have recently shown that afferent activation of the BLA is increased following application of exogenous corticotropin-releasing factor (CRF). Here we examined the impact of chronic unpredictable stress (CUS) on this...

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Identifiers

PMID: 18973598
DOI: 10.1111/j.1460-9568.2008.06451.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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