In vitro and in vivo evaluation of the genotoxicity of N-nitrosooxprenolol.

doi:10.1111/j.1600-0773.1992.tb00536.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In vitro and in vivo evaluation of the genotoxicity of N-nitrosooxprenolol.

Pharmacology & toxicology - 1 Aug 1992

Martelli A, Canonero R, Allavena A, Sottofattori E, Brambilla G

Abstract excerpt

N-nitrosooxprenolol (NO-oxprenolol) might be formed in the stomach of patients taking the beta-adrenergic blocking drug, oxprenolol. This nitroso derivative has previously been shown to induce DNA damage and repair in both rat and human cultured hepatocytes. The results of the present study show that in the presence of co-cultured rat hepatocytes, 0.03 mM NO-oxprenolol produced a significant increase in the...

Topics

Animals
Biotransformation
Cells, Cultured
Cricetinae
Cricetulus
DNA Damage
Drug Resistance
Erythrocytes
Female
Liver
Lung
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutagenicity Tests

Mutation

Nitrosamines

Oxprenolol

Rats

Source

Open in PubMed

Identifiers

PMID: 1438032
DOI: 10.1111/j.1600-0773.1992.tb00536.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1438032-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro and in vivo evaluation of the genotoxicity of N-nitrosooxprenolol.PMID 1438032Read ↗

Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.Semantic proximity Read ↗

Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.Semantic proximity Read ↗

Assessment of genotoxic effects by lindane.Semantic proximity Read ↗

Evaluation of genotoxicity of N-nitrosodibenzylamine in Chinese hamster V79 cells and in Salmonella.Semantic proximity Read ↗

Detection of mutations in bacteria and of DNA damage and amplified DNA sequences in mammalian cells as a systematic test strategy for elucidating biological activities of chemical carcinogens.Semantic proximity Read ↗

Evaluation of the mutagenic potential of ubidecarenone using three short-term assays.Semantic proximity Read ↗

Genotoxicity assessments of N-nitrosoethylisopropylamine (NEIPA) and N-nitrosodiisopropylamine (NDIPA) in the C57BL/6J mouse.Semantic proximity Read ↗

Mutagenicity and effect on gap-junctional intercellular communication of 4,4'-methylenebis(2-chloroaniline) and its oxidized metabolites.Semantic proximity Read ↗

Approaches to Cancer Prevention Based on an Understanding of N-Nitrosamine CarcinogenesisSemantic proximity Read ↗

Genotoxicity of aloeemodin in vitro and in vivo.Semantic proximity Read ↗

Synthesis and in vitro characterization of the genotoxic, mutagenic and cell-transforming potential of nitrosylated heme.Semantic proximity Read ↗

Assessment of the genotoxicity of the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in rat liver epithelial cells in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.