Metabolism and activation of pancreas specific nitrosamines by pancreatic ductal cells in culture.

doi:10.1093/carcin/14.8.1705

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Article

Metabolism and activation of pancreas specific nitrosamines by pancreatic ductal cells in culture.

Carcinogenesis - 1 Aug 1993

Kokkinakis D M, Reddy M K, Norgle J R, Baskaran K

Abstract excerpt

Metabolism of 14C labeled N-nitrosobis(2-oxopropyl)amine (BOP), N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) and N-nitrosobis(2-hydroxypropyl)amine (BHP) by pancreatic duct cells in culture involves the following two pathways: reduction or oxidation reactions at the beta-carbon which resul...

Topics

Animals
Biotransformation
Carbon Radioisotopes
Carcinogens
Cell Transformation, Neoplastic
Cells, Cultured
Cricetinae
DNA
DNA Damage
Male
Mesocricetus
Models, Biological
Mutation
Nitrosamines
Pancreas

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