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Article

Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells.

Mutagenesis - 1 Mar 1990

Heflich R H, Thornton-Manning J R, Kinouchi T, Beland F A

Abstract excerpt

1-Nitropyrene, a tumorigenic environmental pollutant, is mutagenic in Chinese hamster ovary (CHO) cells in the presence of a liver homogenate 9000 g supernatant fraction (S9). The metabolic pathways involved in this response were studied by comparing the mutagenicities at the hypoxanthine-guanine phosphoribosyl transferase locus of 1-nitropyrene, some oxidized microsomal metabolites of 1-nitropyrene, and related...

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PMID: 2188067
DOI: 10.1093/mutage/5.2.151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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