Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells.

doi:10.1093/mutage/5.2.151

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Article

Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells.

Mutagenesis - 1 Mar 1990

Heflich R H, Thornton-Manning J R, Kinouchi T, Beland F A

Abstract excerpt

1-Nitropyrene, a tumorigenic environmental pollutant, is mutagenic in Chinese hamster ovary (CHO) cells in the presence of a liver homogenate 9000 g supernatant fraction (S9). The metabolic pathways involved in this response were studied by comparing the mutagenicities at the hypoxanthine-guanine...

Topics

Animals
Cricetinae
Female
Liver Extracts
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Pyrenes
Rats
Rats, Inbred Strains

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