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Article

A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes.

FEBS letters - 1 Oct 2023

Silveira Daner A, Gupta Shantanu, da Cunha Jaeger Mariane, Brunetto de Farias Caroline, Mombach José Carlos Merino, Sinigaglia Marialva

Abstract excerpt

Ewing sarcoma (ES) is a highly aggressive pediatric tumor driven by the RNA-binding protein EWS (EWS)/friend leukemia integration 1 transcription factor (FLI1) chimeric transcription factor, which is involved in epithelial-mesenchymal transition (EMT). EMT stabilizes a hybrid cell state, boosting metastatic potential and drug resistance. Nevertheless, the mechanisms underlying the maintenance of this hybrid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Identifiers

PMID: 37597508
DOI: 10.1002/1873-3468.14724

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