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Cancer Stem Cells and Chemoresistance in Ewing Sarcoma

28 Jun 2022

Abstract excerpt

Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of stemness genes, pluripotency, high self-renewal ability, and tumor-initiating capability. These cancer stem cells (CSCs) are usually resistant to anticancer drugs and are likely...

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PMID: 35761483
DOI: 10.2174/1574888x17666220627114710

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