Article

Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits

2024-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Pediatric sarcomas are bone and soft tissue tumors that often exhibit high metastatic potential and refractory stem-like phenotypes, resulting in poor outcomes. Aggressive sarcomas frequently harbor a disrupted p53 pathway. However, whether sarcoma stemness is associated with abrogated p53 function and might be attenuated via p53 reactivation remains unclear. Here, we show that highly tumorigeni...

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Literature Corpus work: c192f5f7-da5b-505e-91ab-547afe839be8
DOI: 10.1101/2024.01.17.576012

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