Article
Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory.
Experimental gerontology - 1 Jan 2000
Kawamata T, Akiguchi I, Yagi H, Irino M, Sugiyama H, Akiyama H, Shimada A, Takemura M, Ueno M, Kitabayashi T, Ohnishi K, Seriu N, Higuchi K, Hosokawa M, Takeda T
Abstract excerpt
In a series of inbred Senescence-Accelerated mice (SAM) strains, accelerated-senescence prone SAMP substrains show early onset and rapid advancement of senescence. SAMP8 and SAMP10, in particular, exhibit a significant age-related deterioration in memory and learning for passive and active avoida...
Topics
- Aging
- Animals
- Learning Disabilities
- Memory Disorders
- Mice
- Mice, Inbred Strains
- Neuroaxonal Dystrophies
- Neurons
- Phenotype
- Time Factors