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Systemic ablation of <i>Camkk2</i> impairs metastatic colonization and improves insulin sensitivity in TRAMP mice: Evidence for cancer cell-extrinsic CAMKK2 functions in prostate cancer

2022-03-28

Abstract excerpt

Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolism, whether CAMKK2’s effects on whole body metabolism would impact prostate cancer progression and/or related comorbidities is not known. Here, we demonstrate that ger...

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Literature Corpus work
da1bfd8d-188d-52a4-8868-24b37af08892
DOI
10.1101/2022.03.28.486100
Open publication

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Systemic ablation of <i>Camkk2</i> impairs metastatic colonization and improves insulin sensitivity in TRAMP mice: Evidence for cancer cell-extrinsic CAMKK2 functions in prostate cancerDOI 10.1101/2022.03.28.486100
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