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Article

Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice.

Diabetes - 1 Jun 2010

Guo Hong, Jin Daozhong, Zhang Yuanyuan, Wright Wendy, Bazuine Merlijn, Brockman David A, Bernlohr David A, Chen Xiaoli

Abstract excerpt

OBJECTIVE: Lipocalin (LCN) 2 belongs to the lipocalin subfamily of low-molecular mass-secreted proteins that bind small hydrophobic molecules. LCN2 has been recently characterized as an adipose-derived cytokine, and its expression is upregulated in adipose tissue in genetically obese rodents. The...

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Identifiers

PMID: 20332347
DOI: 10.2337/db09-1735
PMCID: PMC2874698

Genes

LCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20332347-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice.PMID 20332347Read ↗

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The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic healthSemantic proximity Read ↗

STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytesSemantic proximity Read ↗

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A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.Semantic proximity Read ↗

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