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Article

Adhesion to the extracellular matrix is required for interleukin-1 beta actions leading to reactive phenotype in rat astrocytes.

Molecular and cellular neurosciences - 1 Jul 2010

Summers Lauren, Kangwantas Korakoch, Nguyen Loan, Kielty Cay, Pinteaux Emmanuel

Abstract excerpt

The extracellular matrix (ECM) of the brain is essential for homeostasis and normal functions, but is rapidly remodelled during acute brain injury alongside the development of an inflammatory response driven by the cytokine interleukin (IL)-1. Whether the ECM regulates IL-1 actions in astrocytes is completely unknown. The aim of this study was to test the hypothesis that cellular attachment to the ECM is a...

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Identifiers

PMID: 20380881
DOI: 10.1016/j.mcn.2010.03.013
PMCID: PMC3507629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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