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Article

Proteomic analysis of the reactive phenotype of astrocytes following endothelin-1 exposure.

Proteomics - 1 May 2003

Egnaczyk Gregory F, Pomonis James D, Schmidt Julie A, Rogers Scott D, Peters Christopher, Ghilardi Joseph R, Mantyh Patrick W, Maggio John E

Abstract excerpt

Reactive gliosis is an invariant feature of the pathology of central nervous system (CNS) injury and a major determinant of neuronal survival and regeneration. To begin to understand the alterations in astrocyte protein expression that drive glial changes that occur following injury, we used an established model system (endothelin-1 stimulation of hypertrophy) and proteomic analysis to define a discrete set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

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Share to Nerve Regeneration

Share to Protein Processing, Post-Translational

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 12748948
DOI: 10.1002/pmic.200300407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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