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Essential Roles of the Sperm Centrosome in Human Fertilization: Developing the Therapy for Fertilization Failure due to Sperm Centrosomal Dysfunction

1 Jan 2010

Abstract excerpt

Fertilization is a lengthy process that culminates when the male and female pronuclei fuse in the oocyte cytoplasm. The final stage of fertilization is mediated by the sperm centrosome, which induces microtubule organization into the first mitotic spindle. Despite its critical role, only few functional analyses of the sperm centrosome have been performed until now. Here, we review the recent literature with...

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PMID: 20379121
DOI: 10.1620/tjem.220.247

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