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The human sperm basal body is a complex centrosome important for embryo preimplantation development

23 Sept 2021

Abstract excerpt

The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis, has not been directly addressed so far. Using proteomics and immunofluorescence studies, we show here that the human zygote inherits a basal body enriched with centrosomal proteins from the sperm, establishing the first functional centrosome of the new organism....

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PMID: 34581808
DOI: 10.1093/molehr/gaab062

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