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The role of centrosomes in mammalian fertilization and its significance for ICSI

23 Jun 2009

Abstract excerpt

Centrosome integrity is critically important for successful fertilization and embryo development. In humans, the sperm contributes the dominant centrosomal material containing centrioles and centrosomal components onto which oocyte centrosomal proteins assemble after sperm incorporation to form the sperm aster that is essential for uniting sperm and oocyte pronuclei. Increasingly, dysfunctional sperm centrosomes...

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PMID: 19549764
DOI: 10.1093/molehr/gap049

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