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Article

First mitotic spindle formation is led by sperm centrosome-dependent MTOCs in humans

12 Apr 2021

Abstract excerpt

Unlike in mice, multinucleated blastomeres appear at a high frequency in the two-cell-stage embryos in humans. In this Point of View article, we demonstrate that the first mitotic spindle formation led by sperm centrosome-dependent microtubule organizing centers may cause a high incidence of zygotic division errors using human tripronuclear zygotes.

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PMID: 33843613
DOI: 10.1530/rep-21-0061

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