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Article

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.

Atherosclerosis - 1 Dec 2014

Xie Ping, Zhu Hongling, Jia Lin, Ma Yinyan, Tang Weiqing, Wang Youlin, Xue Bingzhong, Shi Hang, Yu Liqing

Abstract excerpt

OBJECTIVE: The correlation between intestinal cholesterol absorption values and plasma low-density lipoprotein-cholesterol (LDL-C) levels remains controversial. Niemann-Pick-C1-Like 1 (NPC1L1) is essential for intestinal cholesterol absorption, and is the target of ezetimibe, a cholesterol absorp...

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Identifiers

PMID: 25463095
DOI: 10.1016/j.atherosclerosis.2014.09.036
PMCID: PMC4262594

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25463095-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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