Article
NPC1L1: evolution from pharmacological target to physiological sterol transporter.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2006
Huff Murray W, Pollex Rebecca L, Hegele Robert A
Abstract excerpt
Niemann-Pick C1-like 1 protein (NPC1L1) was recently shown to be the molecular target of the cholesterol absorption inhibitor class of drugs, of which ezetimibe is the first widely used member. Since its discovery, NPC1L1 has also been shown to play a focal physiological role in intestinal absorption of sterols, including plant sterols and cholesterol. Evidence in support of this new metabolic pathway has been...
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