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Assessment of complex genomic alterations induced by AZT, 3TC, and the combination AZT +3TC.

Drug and chemical toxicology - 1 Jul 2020

Grando Allyne Cristina, Guimarães Nilza Nascimento, de Souza Ana Paula, Lehmann Mauricio, Cunha Kênya Silva, Dihl Rafael Rodrigues

Abstract excerpt

Highly active antiretroviral therapy (HAART) regimens are based on the use of nucleoside reverse transcriptase inhibitors (NRTIs), which are the main drugs used by patients infected with the human immunodeficiency virus (HIV). The use of NRTIs combinations has afforded clear clinical benefits to patients undergoing HAART. However, the combination of two NRTIs may increase the risk of genomic instability in...

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PMID: 30208744
DOI: 10.1080/01480545.2018.1504959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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