Article
In vivo genotoxicity evaluation of efavirenz (EFV) and tenofovir disoproxil fumarate (TDF) alone and in their clinical combinations in Drosophila melanogaster.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2017
de Moraes Filho Aroldo Vieira, de Jesus Silva Carvalho Cláudia, Verçosa Cícero Jorge, Gonçalves Macks Wendhell, Rohde Cláudia, de Melo E Silva Daniela, Cunha Kênya Silva, Chen-Chen Lee
Abstract excerpt
This study focuses on the antiretrovirals efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, and tenofovir disoproxil fumarate (TDF), an oral prodrug of tenofovir analog of adenosine 5'-monophosphate, which belongs to the class of nucleotide reverse transcriptase inhibitors. Both compounds act on the mechanisms of HIV replication, inhibiting the action of reverse transcriptase and thus preventing...
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