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Mitochondrial toxicity and HIV therapy

1 Jun 2001

Abstract excerpt

Nucleoside reverse transcriptase inhibitors (NRTIs) remain the cornerstone of highly active antiretroviral therapy (HAART) combination regimens. However, it has been known for some time that these agents have the potential to cause varied side effects, many of which are thought to be due to their effects on mitochondria. Mitochondria, the key energy generating organelles in the cell, are unique in having their...

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PMID: 11402222
DOI: 10.1136/sti.77.3.158

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