Article
GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency.
Best practice & research. Clinical endocrinology & metabolism - 1 Dec 2006
de Roux Nicolas
Abstract excerpt
Isolated hypogonadotropic hypogonadism (IHH) is defined by a complete or partial impaired secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In the regulation of the gonadotropic axis, the gonadotropin-releasing hormone (GnRH) and its receptor have evolved as a central element in fetal life, at puberty, and for reproduction in adulthood. GnRH resistance due to GnRH receptor (GnRHR)...
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