A <i>GPR54</i> -Activating Mutation in a Patient with Central Precocious Puberty

Abstract excerpt

Gonadotropin-dependent, or central, precocious puberty is caused by early maturation of the hypothalamic-pituitary-gonadal axis. In girls, this condition is most often idiopathic. Recently, a G protein-coupled receptor, GPR54, and its ligand, kisspeptin, were described as an excitatory neuroregulator system for the secretion of gonadotropin-releasing hormone (GnRH). In this study, we have identified an autosomal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hypothalamic control of reproductive hormones
• Share to Neuropeptides and Animal Physiology
• Share to Plant Reproductive Biology