Molecular characterization of a trans-acting, positive effector (ipaR) of invasion plasmid antigen synthesis in Shigella flexneri serotype 5.

doi:10.1016/0882-4010(90)90047-t

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular characterization of a trans-acting, positive effector (ipaR) of invasion plasmid antigen synthesis in Shigella flexneri serotype 5.

Microbial pathogenesis - 1 Mar 1990

Buysse J M, Venkatesan M, Mills J A, Oaks E V

Abstract excerpt

A trans-acting, positive effector of invasion plasmid antigen (Ipa) synthesis has been identified and mapped on the pWR100 invasion plasmid of Shigella flexneri serotype 5 (strain M90T-W). Recombinant plasmids carrying this regulatory gene, designated ipaR, were found to restore full virulence to a non-invasive ipaR::Tn5 insertion mutant [M90T-W(pHS1042)] that had lost the ability to synthesize four Ipa antigens...

Topics

Amino Acid Sequence
Antigens, Bacterial
Bacterial Proteins
Bacteriophages
Base Sequence
DNA Transposable Elements
DNA, Bacterial
Genes, Regulator
Genetic Complementation Test
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Restriction Mapping

Sequence Homology, Nucleic Acid

Shigella flexneri

Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 2166210
DOI: 10.1016/0882-4010(90)90047-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2166210-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular characterization of a trans-acting, positive effector (ipaR) of invasion plasmid antigen synthesis in Shigella flexneri serotype 5.PMID 2166210Read ↗

Characterization of B-cell epitopes on IpaB, an invasion-associated antigen of Shigella flexneri: identification of an immunodominant domain recognized during natural infectionSemantic proximity Read ↗

Genetic analysis of an invasion region by use of a Tn3-lac transposon and identification of a second positive regulator gene, invE, for cell invasion of Shigella sonnei: significant homology of invE with ParB of plasmid P1.Semantic proximity Read ↗

Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri.Semantic proximity Read ↗

Structural analysis of invasion plasmid antigen D (IpaD) from Shigella flexneri.Semantic proximity Read ↗

Genetic and Molecular Basis of Epithelial Cell Invasion by Shigella SpeciesSemantic proximity Read ↗

Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins.Semantic proximity Read ↗

Virulence plasmids of enteroinvasive Escherichia coli and Shigella flexneri integrate into a specific site on the host chromosome: integration greatly reduces expression of plasmid-carried virulence genes.Semantic proximity Read ↗

Sequence variation in two ipaH genes of Shigella flexneri 5 and homology to the LRG-like family of proteins.Semantic proximity Read ↗

Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens.Semantic proximity Read ↗

Characterization of virulence genes of enteroinvasive Escherichia coli by TnphoA mutagenesis: identification of invX, a gene required for entry into HEp-2 cells.Semantic proximity Read ↗

Identification, genetic analysis and DNA sequence of a 7.8-kb virulence region of the Salmonella typhimurium virulence plasmid.Semantic proximity Read ↗

The role of toxin:antitoxin systems and insertion sequences in the loss of virulence in <i>Shigella sonnei</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.