Article
A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant.
Applied microbiology and biotechnology - 1 Feb 2002
Ohnishi J, Mitsuhashi S, Hayashi M, Ando S, Yokoi H, Ochiai K, Ikeda M
Abstract excerpt
Classical whole-cell mutagenesis has achieved great success in development of many industrial fermentation strains, but has the serious disadvantage of accumulation of uncharacterized secondary mutations that are detrimental to their performance. In the post-genomic era, a novel methodology which avoids this drawback presents itself. This "genome-based strain reconstruction" involves identifying mutations by...
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