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Article

Deletion of murine choline dehydrogenase results in diminished sperm motility.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2010

Johnson Amy R, Craciunescu Corneliu N, Guo Zhong, Teng Ya-Wen, Thresher Randy J, Blusztajn Jan K, Zeisel Steven H

Abstract excerpt

Choline dehydrogenase (CHDH) catalyzes the conversion of choline to betaine, an important methyl donor and organic osmolyte. We have previously identified single nucleotide polymorphisms (SNPs) in the human CHDH gene that, when present, seem to alter the activity of the CHDH enzyme. These SNPs occur frequently in humans. We created a Chdh(-/-) mouse to determine the functional effects of mutations that result in...

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Identifiers

PMID: 20371614
DOI: 10.1096/fj.09-153718
PMCID: PMC2909292

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CHDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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