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Article

Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration.

Asian journal of andrology - 1 Sept 2012

Lazaros Leandros, Xita Nectaria, Hatzi Elissavet, Kaponis Apostolos, Makrydimas Georgios, Takenaka Atsushi, Sofikitis Nikolaos, Stefos Theodoros, Zikopoulos Konstantinos, Georgiou Ioannis

Abstract excerpt

Choline is a crucial factor in the regulation of sperm membrane structure and fluidity, and this nutrient plays an important role in the maturation and fertilizing capacity of spermatozoa. Transcripts of phosphatidylethanolamine N-methyltransferase (PEMT) and choline dehydrogenase (CHDH), two basic enzymes of choline metabolism, have been observed in the human testis, demonstrating their gene expression in this...

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Identifiers

PMID: 22387881
DOI: 10.1038/aja.2011.125
PMCID: PMC3734977

Genes

CHDH
PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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