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Article

Structure and analysis of the human dimethylglycine dehydrogenase gene.

Molecular genetics and metabolism - 1 Mar 2000

Binzak B A, Vockley J G, Jenkins R B, Vockley J

Abstract excerpt

Dimethylglycine dehydrogenase (DMGDH; E.C. 1.5.99.2) is an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine (DMG) to form sarcosine. Subsequently, sarcosine dehydrogenase (SDH; E.C. 1.5.99.1) converts sarcosine to glycine via a similar reaction. Both enzymes are found as monomers in the mitochondrial matrix, and both contain 1 mol of covalently bound flavin...

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Source

Identifiers

PMID: 10767172
DOI: 10.1006/mgme.2000.2980

Genes

DMGDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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