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Article

Mutation of Glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease.

Biophysical journal - 7 Apr 2010

Cheng Shu-Chun, Chang Gu-Gang, Chou Chi-Yuan

Abstract excerpt

The maturation of SARS coronavirus involves the autocleavage of polyproteins 1a and 1ab by the main protease (Mpro) and a papain-like protease; these represent attractive targets for the development of anti-SARS drugs. The functional unit of Mpro is a homodimer, and each subunit has a His-41cdots, three dots, centeredCys-145 catalytic dyad. Current thinking in this area is that Mpro dimerization is essential for...

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Identifiers

PMID: 20371333
DOI: 10.1016/j.bpj.2009.12.4272
PMCID: PMC2849084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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