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Article

Folded monomer of HIV-1 protease.

The Journal of biological chemistry - 28 Dec 2001

Ishima R, Ghirlando R, Tözsér J, Gronenborn A M, Torchia D A, Louis J M

Abstract excerpt

The mature human immunodeficiency virus type 1 protease rapidly folds into an enzymatically active stable dimer, exhibiting an intricate interplay between structure formation and dimerization. We now show by NMR and sedimentation equilibrium studies that a mutant protease containing the R87K substitution (PR(R87K)) within the highly conserved Gly(86)-Arg(87)-Asn(88) sequence forms a monomer with a fold similar to...

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Identifiers

PMID: 11598128
DOI: 10.1074/jbc.M108136200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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