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Activation and maturation of SARS-CoV main protease

1 Apr 2011

Abstract excerpt

The worldwide outbreak of the severe acute respiratory syndrome (SARS) in 2003 was due to the transmission of SARS coronavirus (SARS-CoV). The main protease (M(pro)) of SARS-CoV is essential for the viral life cycle, and is considered to be an attractive target of anti-SARS drug development. As a key enzyme for proteolytic processing of viral polyproteins to produce functional non-structure proteins, M(pro) is...

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PMID: 21533772
DOI: 10.1007/s13238-011-1034-1

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