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Article

Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties.

The Journal of biological chemistry - 21 Feb 2003

Louis John M, Ishima Rieko, Nesheiwat Issa, Pannell Lewis K, Lynch Shannon M, Torchia Dennis A, Gronenborn Angela M

Abstract excerpt

Interactions between the C-terminal interface residues (96-99) of the mature HIV-1 protease were shown to be essential for dimerization, whereas the N-terminal residues () and Arg(87) contribute to dimer stability (Ishima, R., Ghirlando, R., Tozser, J., Gronenborn, A. M., Torchia, D. A., and Louis, J. M. (2001) J. Biol. Chem. 276, 49110-49116). Here we show that the intramonomer interaction between the side...

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Identifiers

PMID: 12468541
DOI: 10.1074/jbc.M209726200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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