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Article

Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor.

Communications biology - 1 Mar 2022

Nashed Nashaat T, Aniana Annie, Ghirlando Rodolfo, Chiliveri Sai Chaitanya, Louis John M

Abstract excerpt

The role of dimer formation for the onset of catalytic activity of SARS-CoV-2 main protease (MProWT) was assessed using a predominantly monomeric mutant (MProM). Rates of MProWT and MProM catalyzed hydrolyses display substrate saturation kinetics and second-order dependency on the protein concentration. The addition of the prodrug GC376, an inhibitor of MProWT, to MProM leads to an increase in the dimer...

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Identifiers

PMID: 35233052
DOI: 10.1038/s42003-022-03084-7
PMCID: PMC8888643

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