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Article

Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) .

Biochemistry - 25 May 2010

Barrila Jennifer, Gabelli Sandra B, Bacha Usman, Amzel L Mario, Freire Ernesto

Abstract excerpt

Coronaviruses are responsible for a significant proportion of annual respiratory and enteric infections in humans and other mammals. The most prominent of these viruses is the severe acute respiratory syndrome coronavirus (SARS-CoV) which causes acute respiratory and gastrointestinal infection in humans. The coronavirus main protease, 3CL(pro), is a key target for broad-spectrum antiviral development because of...

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Source

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Identifiers

PMID: 20420403
DOI: 10.1021/bi1002585
PMCID: PMC2877132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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