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Article

Cleavage at the nsp5-nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form.

The Journal of biological chemistry - 1 May 2026

Aniana Annie, Nashed Nashaat T, Ghirlando Rodolfo, Bhandari Dipendra, Kovalevsky Andrey, Louis John M

Abstract excerpt

Our previous studies of severe acute respiratory syndrome coronavirus 2 main protease (MPro) precursor monomer indicate that the initial N-terminal nonstructural protein (nsp)4/nsp5 cleavage occurs intramolecularly, with a small fraction of the active site loop equilibrium being in the active state. To understand the influence of dimer formation of MPro upon N-terminal cleavage on the subsequent C-terminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41866037
DOI: 10.1016/j.jbc.2026.111395
PMCID: PMC13125995

Genes

MBP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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