Article
Detection of populations of amyloid-like protofibrils with different physical properties.
Biophysical journal - 7 Apr 2010
Relini Annalisa, Torrassa Silvia, Ferrando Riccardo, Rolandi Ranieri, Campioni Silvia, Chiti Fabrizio, Gliozzi Alessandra
Abstract excerpt
We used tapping mode atomic force microscopy to study the morphology of the amyloid protofibrils formed at fixed conditions (low pH with high ionic strength) by self-assembly of the N-terminal domain of the hydrogenase maturation factor HypF. Although all protofibrils in the sample share a beaded structure and similar values of height and width, an accurate analysis of contour length and end-to-end distance and...
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