Article
The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver.
Toxicology letters - 16 Jun 2010
Qu Xiaoyu, Metz Richard P, Porter Weston W, Neuendorff Nichole, Earnest Barbara J, Earnest David J
Abstract excerpt
Transcription factors expressing Per-Arnt-Sim (PAS) domains are key components of the mammalian circadian clockworks found in most cells and tissues. Because these transcription factors interact with other PAS genes mediating xenobiotic metabolism and because toxin responses are often marked by daily variation, we determined whether the toxin-mediated activation of the signaling pathway involving several PAS...
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