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Article

Critical cholangiocarcinogenesis control by cryptochrome clock genes.

International journal of cancer - 1 Jun 2017

Mteyrek Ali, Filipski Elisabeth, Guettier Catherine, Oklejewicz Malgorzata, van der Horst Gijsbertus T J, Okyar Alper, Lévi Francis

Abstract excerpt

A coordinated network of molecular circadian clocks in individual cells generates 24-hr rhythms in liver metabolism and proliferation. Circadian disruption through chronic jet lag or Per2 clock gene mutation was shown to accelerate hepatocarcinoma development in mice. As divergent effects were reported for clock genes Per and Cry regarding xenobiotic toxicity, we questioned the role of Cry1 and Cry2 in liver...

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Source

Identifiers

PMID: 28224616
DOI: 10.1002/ijc.30663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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