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Article

Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Toxicology and applied pharmacology - 15 Apr 2012

Yao Cindy Q, Prokopec Stephenie D, Watson John D, Pang Renee, P'ng Christine, Chong Lauren C, Harding Nicholas J, Pohjanvirta Raimo, Okey Allan B, Boutros Paul C

Abstract excerpt

The biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been the subject of intense study for decades. It is now clear that essentially all TCDD-induced toxicities are mediated by DNA-protein interactions involving the Aryl Hydrocarbon Receptor (AHR). Nevertheless, it remains unknown which AHR target genes cause TCDD toxicities. Several groups, including our own, have developed rodent...

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Source

Identifiers

PMID: 22342509
DOI: 10.1016/j.taap.2012.02.001

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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