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Article

Evidence of loss of heterozygosity of the PTCH gene in orthokeratinized odontogenic cyst

8 Dec 2010

Abstract excerpt

The orthokeratinized odontogenic cyst (OOC) is an odontogenic cyst of unknown etiology. Clinical, histological, and biological differences are reported between keratocystic odontogenic tumor (KOT) and OOC. PTCH is a tumor suppressor gene related to sonic hedgehog (SHH) pathway important in embryological development. Considering that alterations in this pathway have been described in sporadic and nevoid basal cell...

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PMID: 21138481
DOI: 10.1111/j.1600-0714.2010.00977.x

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Evidence of loss of heterozygosity of the PTCH gene in orthokeratinized odontogenic cystPMID 21138481Read ↗

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The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI‐1 and bcl‐2 is similar to ameloblastoma but different from odontogenic cystsSemantic proximity Read ↗

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